Hypogonadism, infertility, and sexual dysfunction occur in some men with coeliac disease. We have measured plasma testosterone, dihydrotestosterone, sex-hormone binding globulin, oestradiol, and serum luteinising hormone in 41 men with coeliac disease and have related these findings coeliac disease and hormones jejunal morphology, fertility, semen quality, and sexual function. As jejunal morphology improved hormone levels appeared to return to normal.
This specific combination of abnormalities was not present in any of the disease control groups and, to our knowledge, androgen resistance has not been described previously in any other non-endocrine disorder.
Unlike plasma androgens and serum luteinising hormone in coeliacs, plasma coeliac disease and hormones was not clearly related to jejunal morphology. Androgen resistance and associated hypothalamic-pituitary dysfunction appear to be relatively specific to coeliac disease and cannot be explained merely in terms of malnutrition or chronic ill-health.
In addition, coeliac disease and hormones, our findings suggest that this endocrine disturbance may be related to sexual dysfunction in coeliac disease but its relationship to disordered spermatogenesis in this condition has not been clearly established. National Center for Biotechnology InformationU. Journal List Gut v. This article has been cited by other articles in PMC. Abstract Hypogonadism, infertility, and sexual dysfunction occur in some men with coeliac disease.
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