Clomipraminesold under the brand name Anafranil among others, is a tricyclic antidepressant TCA. Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. Clomipramine was clomipramine and prozac in by the Swiss drug manufacturer Ciba-Geigy.
In a meta-analysis of various trials involving fluoxetine Prozacclomipramine and prozac, fluvoxamine Luvoxand sertraline Zoloft to test their relative efficacies in treating OCD, clomipramine was found to be the most effective. Clomipramine use during pregnancy is associated with congenital heart defects in the newborn.
Clomipramine has been associated with the following side effects: Withdrawal symptoms may occur during gradual or particularly abrupt withdrawal of tricyclic antidepressant drugs. Restarting the antidepressant and slow tapering is the treatment of choice for tricyclic antidepressant withdrawal.
Some withdrawal symptoms may respond to anticholinergicssuch as atropine or benztropine mesylate. Clomipramine overdose usually presents with the following symptoms: There is no specific antidote for overdose and all treatment is purely supportive and symptomatic. Clomipramine may interact with a number of different medications, including the clomipramine and prozac oxidase inhibitors which include isocarboxazidmoclobemidephenelzineselegiline and tranylcypromineantiarrhythmic agents due to the effects of TCAs like clomipramine on cardiac conduction.
There is also a potential pharmacokinetic interaction with quinidine due to the fact that clomipramine is metabolised by CYP2D6 in vivodiuretics due to the potential for hypokalaemia low blood potassium to develop which increases the risk for QT interval prolongation and torsades de pointesthe selective serotonin reuptake inhibitors SSRIs; due to both potential additive serotonergic effects leading to serotonin syndrome and the potential for a pharmacokinetic interaction with the SSRIs that inhibit CYP2D6 [e, clomipramine and prozac.
Clomipramine is a clomipramine and prozac inhibitor of serotonin and norepinephrineor a serotonin—norepinephrine reuptake inhibitor SNRI ; that is, it blocks the reuptake of these neurotransmitters back into neurons by preventing clomipramine and prozac from interacting with their transportersthereby increasing their extracellular concentrations in the synaptic cleft and resulting in increased serotonergic and noradrenergic neurotransmission.
The antidepressant effects of clomipramine are thought to be due to reuptake inhibition of serotonin and norepinephrine,  while serotonin reuptake inhibition only is thought to be responsible for the effectiveness of clomipramine in the treatment of OCD. The exceptionally strong serotonin reuptake inhibition of clomipramine likely precludes the possibility of its antagonism of serotonin receptors which it binds to with more than fold lower affinity than the Clomipramine and prozac resulting in a net decrease in signaling by these receptors.
In accordance, while serotonin receptor antagonists like cyproheptadine and chlorpromazine are effective as antidotes against serotonin syndrome  clomipramine is nonetheless capable of inducing this syndrome, clomipramine and prozac.
Clomipramine is a very strong SRI, clomipramine and prozac. Clomipramine was the first drug that was investigated for and found to be effective in the treatment of OCD. In addition to serotonin reuptake inhibition, clomipramine is also a mild but clinically significant antagonist of the dopamine D 1D 2and D 3 receptors at high concentrations. Although clomipramine is probably more effective in the treatment of OCD compared to SSRIs, it is greatly inferior to them in terms of tolerability and safety due to its lack of selectivity for the SERT and promiscuous pharmacological activity.
Clomipramine is a tricyclic compoundspecifically a dibenzazepineand possesses three rings fused together with a side chain attached in its chemical structure. Clomipramine was developed by Geigy.
Clomipramine is marketed throughout the world mainly under the brand names Anafranil and Clomicalm for use in humans and animals, respectively. Clomipramine has also demonstrated efficacy in treating urine spraying in cats. From Wikipedia, the free encyclopedia, clomipramine and prozac. C Risk not ruled out. S4 Prescription only Clomipramine and prozac Pancytopaenia — an abnormally low amount of all the different types of blood cells in the blood clomipramine and prozac platelets, white blood cells and red blood cells.
Leucopenia — a low white blood cell count. Agranulocytosis — basically a worse form of leucopaenia; a dangerously low white blood cell count which leaves one open to life-threatening infections due to the role of the white autoimmune and allergies clomipramine and prozac in defending the body from invaders.
Thrombocytopenia — an abnormally low amount of platelets in the blood which are essential to clotting and hence this leads to an increased tendency to bruise and bleed, including, clomipramine and prozac, potentially, internally. Eosinophilia — an abnormally high number of eosinophils — the cells that fight off parasitic infections — in the blood. Syndrome of inappropriate secretion of antidiuretic hormone SIADH — a potentially fatal reaction to certain medications that is due to an excessive release of antidiuretic hormone — a hormone that prevents the production clomipramine and prozac urine by increasing the reabsorption of fluids in the kidney — this results in the development of clomipramine and prozac electrolyte abnormalities e.
Glaucoma Oedema local or generalised Alopecia hair loss Hyperpyrexia a high fever that is above Abnormal ECG Anaphylactic and anaphylactoid reactions including hypotension Neuroleptic malignant syndrome NMS — a potentially fatal side effect of antidopaminergic agents such as antipsychotics, clomipramine and prozac, tricyclic antidepressants and antiemetics drugs that relieve nausea and vomiting.
NMS develops over a period of days or weeks and is characterised by the clomipramine and prozac symptoms: Tremor Muscle rigidity Mental status change such as confusion, delirium, mania, hypomania, agitation, coma, etc. Hyperthermia high body temperature Tachycardia high heart rate Blood pressure changes Diaphoresis sweating profusely Diarrhoea Alveolitis allergic pneumonitis with or without eosinophilia Purpura.
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